Repurposing Drugs in Oncology (ReDO) — Chloroquine and Hydroxychloroquine as anti-cancer agents
“Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer.”
“Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy.”
“Thus far, clinical results are mostly in favour of the repurposing of CQ.”
“CQ and HCQ exert effects both on cancer cells and on the tumour microenvironment. In addition to inhibition of the autophagic flux, which is the most studied anti-cancer effect of CQ and HCQ, these drugs affect the Toll-like receptor 9, p53 and CXCR4-CXCL12 pathway in cancer cells.”
“In the tumour stroma, CQ was shown to affect the tumour vasculature, cancer-associated fibroblasts and the immune system.”
“The evidence reviewed in this paper indicates that both CQ and HCQ deserve further clinical investigations in several cancer types.”
This last statement is intentionally putting it mildly. That is because these drugs work WITHOUT the help of Big Pharma’s anti-cancer drugs or radiation therapy. These two actually hinder the effectiveness of CHQ and HCQ.
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