The various inhibitory and immunomodulatory effects of HCQ are schematically drawn. PLA2  phospholipase A2, IL interleukin.TLR toll like receptor, UV ultraviolet

Hydroxychloroquine

A favorable effect of hydroxychloroquine on glucose and lipid metabolism beyond its anti-inflammatory roleHydroxychloroquine Cures Type 2 Diabetes

I wanted to throw this in first. This is the type straightforward research paper that you find when those writing it are not paid off by Big Pharma.

Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Conflict of interest statement: The authors declare no conflicts of interests.

“Hydroxychloroquine (HCQ), a commonly used antimalarial drug in rheumatic diseases, has shown favorable metabolic effects on both glucose control and lipid profiles.”

“HCQ as a treatment for her Sjogren syndrome in addition to a subtle yet measurable improvement in her lipid profile. An increasing body of evidence supports the beneficial impacts of HCQ in various ancillary conditions, including diabetes mellitus and dyslipidemia.”

Hydroxychloroquine Cures Type 2 Diabetes

“In September 2011, she was diagnosed with Sjogren syndrome and was started on HCQ 200 mg once daily. An improvement in her glycemic control as evidenced by self glucose monitoring was noted within 1 month of HCQ therapy, with no remarkable hypoglycemic episodes. Her glycated hemoglobin A1C (HbA1C) was successfully reduced to target in January 2011.”

“After reviewing the literature, our case seems to be the first case report of a patient with type 1 diabetes who had improvement in her glycemic control while on HCQ therapy.”

Hydroxychloroquine Cures Type 2 Diabetes

Hydroxychloroquine Cures Type 2 Diabetes

“Besides its glucose-lowering effect in patients with diabetes, lower fasting blood sugar levels [Penn et al. 2010], as well as hypoglycemia have also been reported with CQ and HCQ in subjects without diabetes.”

” Interestingly, HCQ lowers the incidence of developing diabetes mellitus. In a retrospective cohort of 1127 patients with RA, the use of HCQ was associated with a 71% reduction in the risk of incident diabetes [hazard ratio (HR) 0.29; 95% CI 0.09–0.95; p = 0.04]”

“Demonstrated a 77% reduced incidence of diabetes in patients with RA who took HCQ for longer than 4 years, after adjustment for risk factors of diabetes, disease activity and glucocorticoid use.”

“Similarly, another recent retrospective cohort of 13,905 patients with a diagnosis of either RA or psoriasis reported a lower incidence of diabetes among HCQ and tumor necrosis factor inhibitor users compared with other non-biological disease-modifying antirheumatic drugs (HR 0.54; 95% CI 0.36–0.80)”Hydroxychloroquine Cures Type 2 Diabetes

“The mechanism by which HCQ works to improve glycemic control in patients with type 1 diabetes is not known and our case seems to be the first case report in the literature.”

“A possible reduction in islet-cell autoimmunity by HCQ could be the underlying mechanism since our patient has longstanding type 1 diabetes with no insulin reserve and an effect on insulin resistance is less likely to be the underlying mechanism that led to the improvement in glycemic control.”

“Interestingly, changes in lipoproteins can be detected as early as 3 months after antimalarial therapy.”

“Reductions up to 54% in triglycerides (TGs), TC and apolipoprotein CIII levels have been reported in HCQ users in 18 women with mild or inactive SLE compared with nonusers. Furthermore, in a large longitudinal study involving 1260 patients with SLE, the use of antimalarials was negatively correlated with TC (p < 0.0001)”

“In addition, in a prospective randomized trial, Mundor and colleagues reported an overall increase of 15% in HDL-C in HCQ users in a population of patients with RA after 12 months of therapy compared with a decrement of 12% in patients treated with gold (p = 0.006)”Hydroxychloroquine Cures Type 2 Diabetes

“This case and review highlight the need to re-examine HCQ as a potential therapy for T2DM and consider its use especially in patients with rheumatism and diabetes.”

“Favorable lipid-lowering and antidiabetic properties of HCQ renders this drug an attractive medical option. Given the elevated cardiovascular risk associated with RA and SLE, the addition of HCQ to patients’ usual treatment could counteract the dyslipidemic effect of glucocorticoids, resulting in a potential minimization of atheroma progression and thus possibly lowering mortality due to cardiovascular diseases.”

Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Conflict of interest statement: The authors declare no conflicts of interests.

journals.sagepub.com/doi/10.1177…

 

  • Hydroxychloroquine Cures Diabetes

Repositioning of Hydroxychloroquine for Type 2 Diabetes

Hydroxychloroquine Cures Type 2 Diabetes

“A preclinical study conducted by Emami et al demonstrated that HCQ, by increasing intracellular pH, inhibits proteolytic enzymes responsible for degradation of insulin. Hence, the available insulin remains for a longer time.”

Hydroxychloroquine Cures Type 2 Diabetes

“Use of HCQ for 6 weeks in obese, non-diabetic subjects is associated with significant increase in insulin sensitivity index and trend towards reduced insulin resistance and insulin secretion”

“These results show a reduction in diabetes risk of up to 77% for patients taking HCQ for more than 4 years, a finding that is comparable or superior to that of other drugs studied in clinical trials”

“HCQ can emerge as an effective and well-tolerated treatment option for type 2 diabetes mellitus patients uncontrolled on sulfonylurea
and metformin combination”

Hydroxychloroquine Cures Type 2 Diabetes

“HCQ treated patients showed a significant fall in total cholesterol and
low-density lipoprotein from baseline. HCQ was found to be safe and well-tolerated”

jmgims.co.in/temp/JMahatmaGandhi…

Efficacy & safety of Hydroxychloroquine in the treatment of type 2 diabetes mellitus: a double blind, randomized comparison with pioglitazone

Hydroxychloroquine Cures Type 2 Diabetes

Hydroxychloroquine Cures Type 2 Diabetes

“Safe and well tolerated”

“Hydroxychloroquine may emerge as a well tolerated therapeutic option for T2DM patients uncontrolled on conventional therapy.”

researchgate.net/profile/Nihal_T…

 

Mechanism of Uncoating of Influenza B Virus in MDCK Cells: Action of Chloroquine

Hydroxychloroquine Chloroquine Influenza Flu Infection Vaccination

“Exposure of influenza B virus-infected MDCK cells to chloroquine at the time of infection resulted in significant inhibition of infection.”

“It is likely that chloroquine prevents the uncoating of influenza B virus by increasing the lysosomal pH above the critical value required for inducing fusion between the virus envelope and the lysosomal membrane.”

Hydroxychloroquine Chloroquine Influenza Flu Infection Vaccination

“The normal pH inside the lysosomes was around 5-6. This value was within the pH range optimal for the haemolysis reaction by influenza B virus. When chloroquine was added to the culture, the lysosomal pH rapidly increased to 6-5, which is above the critical value required for haemolysis by influenza B virus.”

“These findings indicate that extracellular chloroquine is essential for the maintenance of elevated pH inside the lysosomes.”

Hydroxychloroquine Chloroquine Influenza Flu Infection Vaccination

“These results suggest that chloroquine inhibits infection by acting
at a replicative step preceding primary transcription of the virus genome. Similar conclusions have also been reported for the effect of another lipophilic amine, amantadine, on influenza A viral replication.”

Hydroxychloroquine Chloroquine Influenza Flu Infection Vaccination

Actinomycin D completely inhibited the growth of influenza B virus in MDCK cells when added within 2 h after infection, as observed with influenza A virus.”

Chloroquine inhibits infection by acting at a step preceding the primary transcription of the influenza B virus genome”Hydroxychloroquine Chloroquine Influenza Flu Infection Vaccination

“Further experiments were carried out to confirm that elevation of the lysosomal pH by chloroquine is responsible for its inhibition of infection.

microbiologyresearch.org/content…

 

  • #HCQWorks

The Chlorine Dioxide in CloSYS  mouthwash kills SARS-CoV!CloSYS Mouthwash SARS-CoV-2 Chlorine Dioxide COVID

CloSYS Mouthwash SARS-CoV-2 Chlorine Dioxide COVID

“In vitro studies have shown that CloSYS, an over the counter mouthwash containing ClO2, was effective on inactivating SARS-CoV as well as disinfecting infected surfaces, dental unit waterlines, and biofilms in ultrasonic dental scaling units.”

(more…)

  • Closys QPlusNews Chlorine Dioxide

The effect of Hydroxychloroquine on alloreactivity and its potential use for graft-versus-host disease

Hydroxychloroquine COVID Graft-Versus-Host Disease Q Plus News

“Hydroxychloroquine (HCQ) interferes with antigen processing and with receptor loading and recycling by raising the pH of lysosomes and endosomes.”

(more…)

Boosted Influenza Flu Vaccine VIQCC & COVID-19 Outbreak Italy

“It looks like this “super” vaccine impacted the immune system in such a way to increase coronavirus infection through virus interference that set the stage for what happened in Italy.”

  • Does the flu shot increase the risk for coronavirus infection? YES!
  • Could a new flu vaccine be partly responsible for the COVID-19 mortality rate in Italy?  YES!
  • Is the rush to a vaccine the best solution? No, it could bring catastrophic results.
  • How does the SARS-CoV-2 infect and are protease enzyme supplements the key to creating our own endogenous antiviral protease inhibitors? Yes, I believe so!
  • Are there certain medications like blood pressure drugs and proton pump inhibitors that increase risk for infection and mortality?  YES
  • Is it chloroquine or is it zinc that is working as a possible aid in treating COVID-19? A strong case can be made for zinc!
  • Can plant polyphenols and flavonoids act to increase the antiviral effects of zinc? YES! And they possess other benefits too!

doctormurray.com/does-the-flu-sh…